An example of the benefit of gene drives is that they can be designed so that female mosquitoes express infertility eventually reducing the spread of mosquito-borne pathogens such as those that cause Zika, malaria, dengue, and yellow fever. However, this ability to rapidly alter wild populations could also be misused, which poses novel security risks for entomological warfare, agro-sabotage, and ecocide. The authors offer a case study of how scientists could use synthetic engineering to change the eye color of subsequent generations of mosquitoes.