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Monsanto suffered a major setback Tuesday when a federal judge in San Francisco unsealed documents that call into question the agrichemical giant's research practices and the safety of its best-selling herbicide, Roundup, the world's most-produced weedkiller. The documents counter industry-funded research that has long asserted Monsanto's flagship product—used by home gardeners, public park gardeners and farmers and applied to hundreds of crops—is relatively safe.