02.05.2020 | permalink
Testing could start this summer in Florida Keys
Second test would be in heavily populated Houston
The EPA on Friday granted permission for genetically engineered mosquitoes to be released into the Florida Keys and around Houston to see if they can help limit the spread of mosquito-borne illnesses.
British biotech company Oxitec Ltd was granted an experimental use permit to release a genetically engineered type of the mosquito species Aedes aegypti, which is a known vector of Zika virus and viruses that cause yellow fever and dengue fever, the Environmental Protection Agency office of Chemical Safety and Pollution announced.
Oxitec must get state and local approval before it can start field testing. But if granted, testing will take place over a two-year period in Monroe County, Fla., starting this summer, and in Harris County, Texas, beginning in 2021.
02.04.2020 | permalink
Editing tool is found to be prone to making off-target "nicks" in DNA
The gene-editing tool known as CRISPR-Cas12a or Cpf1 has been viewed as a better choice than other Cas editing tools because it was believed to be more precise and less prone to making off-target cuts in DNA.
But a new paper shows that Cpf1 is not as clean or specific as touted. The researchers employed in vitro assays using a vast collection of synthesized DNA molecules containing variations on the editing site sequence. They found that Cpf1 was highly prone to making off-target single-strand cuts, or "nicks", in the double-stranded DNA molecules. Off-target double-strand DNA cuts were also found, albeit at a lower frequency than the single-strand nicks.
31.03.2020 | permalink
Monsanto will pay a $39.5 million class action settlement for falsely claiming that Roundup weed-killer targets an enzyme that is only found in plants.
The issue was that Monsanto promoted Roundup’s safety for people and pets by claiming that glyphosate, the active weed-killing chemical, targets an enzyme that is only found in plants.
The lawsuit claimed that the enzyme is actually found in people and pets, where it is essential for maintaining the immune system, digestion, and brain function.
26.03.2020 | permalink
By Neal Baer, a television writer and producer and lecturer on global health and social medicine at Harvard Medical School.
(.....)
As a television writer and producer of “ER,” “SVU,” and most recently “Designated Survivor,” I draw on audiences’ love-hate relationship with uncertainty to play on their emotions. I know that audiences love plots riven with unexpected twists and turns.
When we’ve emerged on the other side of the pandemic, Covid-19 will someday make a good story. But I worry that CRISPR could make Covid-19 look like child’s play.
CRISPR is a new genetic tool that lets scientists cut out a DNA sequence in an organism’s genome and replace it with another. The hope is that this ingenious scissors-and-glue system will be used to treat devastating genetic diseases like sickle cell anemia and beta thalassemia.
But there’s a dark side to CRISPR. A scientist or biohacker with basic lab know-how could conceivably buy DNA sequences and, using CRISPR, edit them to make an even more panic-inducing bacteria or virus. What’s to stop a rogue scientist from using CRISPR to conjure up an even deadlier version of Ebola or a more transmissible SARS?
19.03.2020 | permalink
The Center for Food Safety has asked the Ninth Circuit U.S. Court of Appeals to review a Food and Drug Administration (FDA) decision to approve soy leghemoglobin as a color additive for use in ground beef analog products. The advocacy group claims that the FDA’s decision was not based on “convincing evidence” that is required by regulation.
The FDA approval of a genetically engineered (GE) soy protein used in the” Impossible Burger” over objections by CFS. The ingredient is also referred to as genetically engineered “heme,” soy leghemoglobin. It is the color additive Impossible Foods uses to make its plant-based burger appear to “bleed” as if it were real beef.
The March 17 civil action by CFS asserts that FDA used the wrong legal standard when it reviewed and approved GE heme to be used in raw Impossible Burgers sold in grocery stores. Instead of using the color additive safety standard that specifies “convincing evidence that establishes with reasonable certainty that no harm will result from the intended use of the color additive,” FDA conflated that standard with the food additive safety standard, which does not specify that there must be “convincing evidence.”
12.03.2020 | permalink
The research, used to help avoid a ban, claimed ‘severe impacts’ on farming if glyphosate was outlawed
Monsanto secretly funded academic studies indicating “very severe impacts” on farming and the environment if its controversial glyphosate weedkiller were banned, an investigation has found.
The research was used by the National Farmers’ Union and others to successfully lobby against a European ban in 2017. As a result of the revelations, the NFU has now amended its glyphosate information to declare the source of the research.
Monsanto was bought by the agri-chemical multinational Bayer in 2018 and Bayer said the studies’ failure to disclose their funding broke its principles. However, the authors of the studies said the funding did not influence their work and the editor of the journal in which they were published said the papers would not be retracted or amended.
25.02.2020 | permalink
The standard gene-editing tool, CRISPR-Cas9, frequently produces a type of DNA mutation that ordinary genetic analysis misses, claims new research published in the journal Science Advances. In describing these findings the researchers called such oversights “serious pitfalls” of gene editing (Skryabin et al., 2020). In all, the new results suggest that gene-editing is more error-prone than thought and, further, that identifying and discarding defective and unwanted outcomes is not as easy as generally supposed.
14.02.2020 | permalink
CAPE GIRARDEAU, MISSOURI: Late this afternoon, a jury in a U.S. District Court in Cape Girardueu, Missouri issued a verdict finding Bayer and BASF liable for plaintiff Bader Farms’ 30,000+ damaged peach trees due to drifting of the broad spectrum herbicide dicamba. Bader Farms was awarded $15 million in damages, with the amount of punitive damages to be decided Saturday.
This verdict was issued amidst reports of an ongoing dicamba drift crisis — reported cases of dicamba drift are up in Indiana, Arkansas, Iowa, and Illinois.
Linda Wells, Pesticide Action Network Organizing Director, issued the following statement:
“This verdict is just the tip of the iceberg — there is a long queue of farmers who have been impacted by dicamba drift and deserve their day in court. The internal Monsanto (now Bayer) documents uncovered in this case show that the company released a highly destructive and intentionally untested product onto the market, and used its influence to cheat the regulatory system.
08.01.2020 | permalink
FEATURE
A new genetic engineering technology could help eliminate malaria and stave off extinctions — if humanity decides to unleash it.
(.....)
What made the gene drive truly strange and remarkable, though, was that it didn’t stop with one set of offspring. Generation after generation, it would relentlessly copy and paste the gene it carried, until it was present in every descendant. “For most of the people in the room, you could tell it was the first they’d heard of this,” James recalled. “You could see their eyes getting big.”
21.12.2019 | permalink
Researchers assumed that CRISPR was turning off genes. They shouldn’t have.
Every living cell on Earth has proteins. Typically thousands of them, that serve as molecular machines to digest food, sense the environment, or anything else a cell must do. However, many genes, and the proteins they code for, have unknown functions. In humans, the function of about 1 out of 5 of genes is unknown. To explore these dark corners of the genome, scientists can break up DNA to disable a gene, making their encoded proteins nonfunctional, and watch what happens to cells as a result, inferring the lost function from what goes wrong.
When CRISPR/Cas9 came online in 2012, it offered scientists a tool to do exactly this – cut genes. The Cas9 enzyme searches through DNA, using a “guide RNA” to look for a specific sequence, and makes a cut when it finds a match. The gene, split in two, is repaired by the cell, but often with a large chunk missing. Many scientists assume that if a chunk of a gene is missing then the protein that it encodes will not function, or even be produced.
In many cases, they would be terribly wrong.